Journal Publications


Observational cohort study of IP-10’s potential as a biomarker to aid in inflammation regulation within a clinical decision support protocol for patients with severe COVID-19

Shaul Lev, Tamar Gottesman, Gal Sahaf Levin, Doron Lederfein, Evgeny Berkov, Dror Diker,Aliza Zaidman, Amir Nutman, Tahel Ilan Ber, Alon Angel, Lior Kellerman, Eran Barash, Roy Navon, Olga Boico, Yael Israeli, Michal Rosenberg, Amir Gelman, Roy Kalfon, Einav Simon, Noa Avni, Mary Hainrichson, Oren Zarchin, Tanya M. Gottlieb, Kfir Oved, Eran Eden, Boaz Tadmor

PLOS ONE | https://doi.org/10.1371/journal.pone.0245296 January 12, 2021

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European Journal of Clinical Microbiology & Infectious Diseases 

A host-protein signature is superior to other biomarkers for differentiating between bacterial and viral disease in patients with respiratory infection and fever without source: a prospective observational study.

Ashkenazi-Hoffnung L, Oved K, Navon R, Friedman T, Boico O, Paz M, Kronenfeld G, Etshtein L, Cohen A, Gottlieb TM, Eden E, Chistyakov I, Srugo I, Klein A, Ashkenazi S, Scheuerman O.

Eur J Clin Microbiol Infect Dis. 2018 Apr 26. doi: 10.1007/s10096-018-3261-3

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Diagnostic Microbiology &

Infectious Disease

A novel host-protein assay outperforms routine parameters for distinguishing between bacterial and viral lower respiratory tract infections.

Stein M, Lipman-Arens S, Oved K, Cohen A, Bamberger E, Navon R, Boico O, Friedman T, Etshtein L, Paz M, Gottlieb TM, Kriger O, Fonar Y, Pri-Or E, Yacobov R, Dotan Y, Hochberg A, Grupper M, Chistyakov I, Potasman I, Srugo I, Eden E, Klein A

Diagn Microbiol Infect Dis. 2018 Mar;90(3):206-213. doi: 10.1016/j.diagmicrobio.2017.11.011

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Assessing the Febrile Child for Serious Infection: A Step Closer to Meaningful Rapid Results.

David W. Kimberlin, Claudette L. Poole

Pediatrics. 2017 Oct;140(4). pii: e20171210. doi: 10.1542/peds.2017-1210

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van Houten CB, de Groot JAH, Klein A, Srugo I, Chistyakov I, de Waal W, Meijssen CB, Avis W, Wolfs TFW, Shachor-Meyouhas Y, Stein M, Sanders EAM, Bont LJ

Lancet Infect Dis. 2017 Apr;17(4):431-440. doi: 10.1016/S1473-3099(16)30519-9

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Srugo I, Klein A, Stein M, Golan-Shany O, Kerem N, Chistyakov I, Genizi J, Glazer O, Yaniv L, German A, Miron D, Shachor-Meyouhas Y, Bamberger E, Oved K, Gottlieb TM, Navon R, Paz M, Etshtein L, Boico O, Kronenfeld G, Eden E, Cohen R, Chappuy H, Angoulvant F, Lacroix L, Gervaix A

Pediatrics. 2017 Oct;140(4). pii: e20163453. doi: 10.1542/peds.2016-3453

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Validation of a Novel Assay to Distinguish Bacterial and Viral Infections.

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Eden E, Srugo I, Gottlieb T, Navon R, Boico O, Cohen A, Bamberger E, Klein A, Oved K

J Infect. 2016 Aug;73(2):177-80. doi: 10.1016/j.jinf.2016.05.002

Journal of Infection

Diagnostic Accuracy of a TRAIL, IP-10 and CRP Combination for Discriminating Bacterial and Viral Etiologies at the Emergency Department.

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Oved K, Cohen A, Boico O, Navon R, Friedman T, Etshtein L, Kriger O, Bamberger E, Fonar Y, Yacobov R, Wolchinsky R, Denkberg G, Dotan Y, Hochberg A, Reiter Y, Grupper M, Srugo I, Feigin P, Gorfine M, Chistyakov I, Dagan R, Klein A, Potasman I, Eden E.

PLoS One. 2015 Mar 18;10(3):e0120012. doi: 10.1371/journal.pone.0120012

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A Novel Host-Proteome Signature for Distinguishing between Acute Bacterial and Viral Infections.

Future Microbiology

A Multifaceted ‘omics’ Approach for Addressing The Challenge of Antimicrobial Resistance.

Cohen A, Bont L, Engelhard D, Moore E, Fernández D, Kreisberg-Greenblatt R, Oved K, Eden E, Hays JP

Future Microbiol. 2015;10(3):365-76. doi: 10.2217/fmb.14.127

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Future Science

Automating a New Host-protein Assay for Differentiating Bacterial from Viral Infection to Reduce Operator Hands-on time.

Shapira M, Boico O, Cohen A, Sagi R, Aharon A, Navon R, Kronenfeld G, Maler K, Pri-Or E, Stein M, Klein A, Eden E, Oved K

BioTechniques. 2018 Aug;65:93-95. doi: 10.2144/btn-2018-0028

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International Conferences

AACC 2020  Virtual Conference

Use of Real Time IP-10 Measurements for Identification and Monitoring of the Dysregulated Immune Response in COVID-19 Patients

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A Host-Response Signature Based on TRAIL, IP-10 and CRP Addresses Antibiotic Misuse Driven by Diagnostic Uncertainty

A Host-Response Signature Based on TRAIL

A TRAIL/IP-10/CRP host-protein assay for distinguishing between bacterial and viral infection has potential to reduce antibiotic overuse in adults with Lower Respiratory Tract Infection (LRTI): preliminary results from the OBSERVER clinical study

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IDWEEK 2020 - Virtual Conference

Use of Real Time IP-10 Measurements to Identify and Monitor the Dysregulated Immune Response in COVID 19 Patients

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ECCVID 2020 - Virtual Conference

Correlation of a Novel Host Biomarker, TRAIL, with ARS-CoV-2 Positivity and its Potential to Stratify COVID-19 Disease Severity


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ID week 2018 - San Francisco, USA

Using the host immune response to identify viral-bacterial coinfection in children with respiratory syncytial virus infection.

Oral presentation

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A host-response assay distinguishes between simple influenza patients and patients with bacterial coinfection.

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ECCMID 2018 - Madrid, Spain

Evaluating performance and utility of a novel host-protein assay in mild acute infections.
Oral presentation

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ESPID 2018  Malmo, Sweden

Determining viral etiology: TRAIL biomarker levels and molecular viral detection in the AutoPilot-Dx study.

TRAIL, IP-10, CRP, and ImunnoXpert™ levels in children with acute respiratory tract infections - an interim analysis from the AutoPilot-Dx study.

Evaluating the potential clinical utility of a host-protein signature for distinguishing between bacterial and viral disease in febrile children.

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ESPID 2017 - Madrid, Spain

Evaluating a novel host-immune based assay for distinguishing bacterial from various viral infections in febrile children.

Selected best e-poster presentation

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ECCMID 2017 - Vienna, Austria

Double-blind validation in febrile children of host-protein assay [TRAIL, IP-10, CRP] for distinguishing bacterial and viral infections.

Adoption of a novel host-protein signature in the workflow of acute febrile illnesses at Hillel Yaffe medical center.

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AACC 2017 - San Diego, USA

Evaluating a novel host immune-based assay for distinguishing bacterial from various viral infections in febrile children.

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ID Week 2017 - San Diego, USA

A novel host-protein assay accurately distinguishes bacterial from viral upper respiratory tract infections.

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Molecular Dx Europe - Lisbon, Portugal

Redefining the set of solutions for antibiotics misuse using host response-based diagnostics

A podcast by Dr. Kfir Oved

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ECCMID 2016 - Amsterdam, Netherlands

A novel host-protein signature outperforms standard
laboratory parameters in the differential diagnosis of lower respiratory tract infections.

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Pioneer Eran Eden and his MeMed team from Israel invented the impossible – a bloodtest that tells you if you are suffering from a bacterial or a viral infection and whether you should be treated with antibiotics or a simple chicken soup.

DLD Conference 2016 - Munich, Germany

When The Drugs Don´t Work

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ID Week 2016 - New Orleans, USA

TNF-related apoptosis-inducing ligand (TRAIL) protein as a marker for disease severity in patients with acute infection.

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AACC 2015 - Atlanta, USA

A Novel Immunoassay that distinguishes between Bacterial and Viral Infections Based on a Patient’s Immune Response.

Distinguished abstract award

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ID Week 2015 - San Diego, USA

A Novel Host-Protein Signature Outperforms Standard Laboratory Parameters in Differential Diagnosis of Acute Infection Etiology of Febrile Children.

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EuroMedLab 2015 - Paris, France

Automated ELISA measurements of host-immune biomarkers for distinguishing between acute bacterial and viral infections.

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ICAAC 2015 - San Diego, USA

Validation of a novel host response based assay for diagnosis of acute infectious etiology in febrile children: a blinded retrospective observational study.



ESPID 2015 - Leipzig, Germany

Combining viral- and bacterial-induced host proteins for diagnosing serious bacterial infections in febrile children.

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WSPID 2015 - Rio de Janeiro, Brazil

Mapping the co-occurrence of bacteria and viruses in healthy and febrile children.

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ESPID 2014 - Dublin, Ireland

A novel host-proteome signature to distinguish between acute bacterial and viral infections in febrile children.

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