Journal Publications
Niv Samuel Mastboim, Alon Angel, Oded Shaham, Tahel Ilan Ber, Roy Navon, Einav Simon, Michal Rosenberg, Yael Israeli, Mary Hainrichson, Noa Avni, Eran Reiner, Paul Feigin, Kfir Oved, Boaz Tadmor, Pierre Singer, Ilya Kagan, Shaul Lev, Dror Diker, Amir Jarjou’i, Ramzi Kurd, Eli Ben-Chetrit, Guy Danziger, Cihan Papan, Sergey Motov, Ma’anit Shapira, Michal Stein, Adi Klein, Tanya M Gottlieb, Eran Eden
doi: https://doi.org/10.1101/2021.06.27.21259196
Journal of Infection
Distinguishing bacterial versus non-bacterial causes of febrile illness – A systematic review of host biomarkers
B. Leticia Fernandez-Carballo; Camille Escadafal; Emily MacLean; Anokhi J. Kapasi; Sabine Dittrich
REVIEW | VOLUME 82, ISSUE 4, P1-10, APRIL 01, 2021
PLOS ONE
Observational cohort study of IP-10’s potential as a biomarker to aid in inflammation regulation within a clinical decision support protocol for patients with severe COVID-19
Shaul Lev, Tamar Gottesman, Gal Sahaf Levin, Doron Lederfein, Evgeny Berkov, Dror Diker,Aliza Zaidman, Amir Nutman, Tahel Ilan Ber, Alon Angel, Lior Kellerman, Eran Barash, Roy Navon, Olga Boico, Yael Israeli, Michal Rosenberg, Amir Gelman, Roy Kalfon, Einav Simon, Noa Avni, Mary Hainrichson, Oren Zarchin, Tanya M. Gottlieb, Kfir Oved, Eran Eden, Boaz Tadmor
PLOS ONE | https://doi.org/10.1371/journal.pone.0245296 January 12, 2021
European Journal of Clinical Microbiology & Infectious Diseases
A host-protein signature is superior to other biomarkers for differentiating between bacterial and viral disease in patients with respiratory infection and fever without source: a prospective observational study.
Ashkenazi-Hoffnung L, Oved K, Navon R, Friedman T, Boico O, Paz M, Kronenfeld G, Etshtein L, Cohen A, Gottlieb TM, Eden E, Chistyakov I, Srugo I, Klein A, Ashkenazi S, Scheuerman O.
Eur J Clin Microbiol Infect Dis. 2018 Apr 26. doi: 10.1007/s10096-018-3261-3
Diagnostic Microbiology & Infectious Disease
A novel host-protein assay outperforms routine parameters for distinguishing between bacterial and viral lower respiratory tract infections.
Stein M, Lipman-Arens S, Oved K, Cohen A, Bamberger E, Navon R, Boico O, Friedman T, Etshtein L, Paz M, Gottlieb TM, Kriger O, Fonar Y, Pri-Or E, Yacobov R, Dotan Y, Hochberg A, Grupper M, Chistyakov I, Potasman I, Srugo I, Eden E, Klein A
Diagn Microbiol Infect Dis. 2018 Mar;90(3):206-213. doi: 10.1016/j.diagmicrobio.2017.11.011
Lancet Infectious Diseases
A Host-Protein Based Assay to Differentiate between Bacterial and Viral Infections in Preschool Children (OPPORTUNITY): A Double-Blind, Multicentre, Validation Study.
van Houten CB, de Groot JAH, Klein A, Srugo I, Chistyakov I, de Waal W, Meijssen CB, Avis W, Wolfs TFW, Shachor-Meyouhas Y, Stein M, Sanders EAM, Bont LJ
Lancet Infect Dis. 2017 Apr;17(4):431-440. doi: 10.1016/S1473-3099(16)30519-9
Srugo I, Klein A, Stein M, Golan-Shany O, Kerem N, Chistyakov I, Genizi J, Glazer O, Yaniv L, German A, Miron D, Shachor-Meyouhas Y, Bamberger E, Oved K, Gottlieb TM, Navon R, Paz M, Etshtein L, Boico O, Kronenfeld G, Eden E, Cohen R, Chappuy H, Angoulvant F, Lacroix L, Gervaix A
Pediatrics. 2017 Oct;140(4). pii: e20163453. doi: 10.1542/peds.2016-3453
Journal of Infection
Diagnostic Accuracy of a TRAIL, IP-10 and CRP Combination for Discriminating Bacterial and Viral Etiologies at the Emergency Department.
Eden E, Srugo I, Gottlieb T, Navon R, Boico O, Cohen A, Bamberger E, Klein A, Oved K
J Infect. 2016 Aug;73(2):177-80. doi: 10.1016/j.jinf.2016.05.002
PLOS ONE
A Novel Host-Proteome Signature for Distinguishing between Acute Bacterial and Viral Infections.
Oved K, Cohen A, Boico O, Navon R, Friedman T, Etshtein L, Kriger O, Bamberger E, Fonar Y, Yacobov R, Wolchinsky R, Denkberg G, Dotan Y, Hochberg A, Reiter Y, Grupper M, Srugo I, Feigin P, Gorfine M, Chistyakov I, Dagan R, Klein A, Potasman I, Eden E.
PLoS One. 2015 Mar 18;10(3):e0120012. doi: 10.1371/journal.pone.0120012
Future Microbiology
A Multifaceted ‘omics’ Approach for Addressing The Challenge of Antimicrobial Resistance.
Cohen A, Bont L, Engelhard D, Moore E, Fernández D, Kreisberg-Greenblatt R, Oved K, Eden E, Hays JP
Future Microbiol. 2015;10(3):365-76. doi: 10.2217/fmb.14.127
Future Science
Automating a New Host-protein Assay for Differentiating Bacterial from Viral Infection to Reduce Operator Hands-on time.
Shapira M, Boico O, Cohen A, Sagi R, Aharon A, Navon R, Kronenfeld G, Maler K, Pri-Or E, Stein M, Klein A, Eden E, Oved K
BioTechniques. 2018 Aug;65:93-95. doi: 10.2144/btn-2018-0028
International
Conferences
ECCMID - 2021 Virtual Conference
Observer “A host assay comprising TRAIL, IP-10 and CRP can improve antibiotic treatment decisions for viral PCR positive adults by accurately ruling out co-infection”
Autopilot: “A host-based assay comprising TRAIL, IP-10 and CRP outperforms procalcitonin in accurately distinguishing bacterial from viral infections in febrile children”
AACC 2020 Virtual Conference
Use of Real Time IP-10 Measurements for Identification and Monitoring of the Dysregulated Immune Response in COVID-19 Patients
A Host-Response Signature Based on TRAIL, IP-10 and CRP Addresses Antibiotic Misuse Driven by Diagnostic Uncertainty
A TRAIL/IP-10/CRP host-protein assay for distinguishing between bacterial and viral infection has potential to reduce antibiotic overuse in adults with Lower Respiratory Tract Infection (LRTI): preliminary results from the OBSERVER clinical study
IDWEEK 2020 - Virtual Conference
Use of Real Time IP-10 Measurements to Identify and Monitor the
Dysregulated Immune Response in COVID 19 Patients
ECCVID 2020 - Virtual Conference
Correlation of a Novel Host Biomarker, TRAIL, with ARS-CoV-2 Positivity and its Potential to Stratify COVID-19 Disease Severity
E-poster
ID week 2018 - San Francisco, USA
Using the host immune response to identify viral-bacterial coinfection in children with respiratory syncytial virus infection.
Oral presentation
A host-response assay distinguishes between simple influenza patients and patients with bacterial coinfection.
ECCMID 2018 - Madrid, Spain
Evaluating performance and utility of a novel host-protein assay in mild acute infections.
Oral presentation
ESPID 2018 Malmo, Sweden
Determining viral etiology: TRAIL biomarker levels and molecular viral detection in the AutoPilot-Dx study.
TRAIL, IP-10, CRP, and ImunnoXpert™ levels in children with acute respiratory tract infections - an interim analysis from the AutoPilot-Dx study.
Evaluating the potential clinical utility of a host-protein signature for distinguishing between bacterial and viral disease in febrile children.
ID week 2018 - San Francisco, USA
Using the host immune response to identify viral-bacterial coinfection in children with respiratory syncytial virus infection.
Oral presentation
A host-response assay distinguishes between simple influenza patients and patients with bacterial coinfection.
IDWEEK 2020 - Virtual Conference
Use of Real Time IP-10 Measurements to Identify and Monitor the
Dysregulated Immune Response in COVID 19 Patients
IDWEEK 2020 - Virtual Conference
Use of Real Time IP-10 Measurements to Identify and Monitor the
Dysregulated Immune Response in COVID 19 Patients
ESPID 2017 - Madrid, Spain
Evaluating a novel host-immune based assay for distinguishing bacterial from various viral infections in febrile children.
Selected best e-poster presentation
AACC 2017 - San Diego, USA
Evaluating a novel host immune-based assay for distinguishing bacterial from various viral infections in febrile children.
ID Week 2017 - San Diego, USA
A novel host-protein assay accurately distinguishes bacterial from viral upper respiratory tract infections.
Molecular Dx Europe - Lisbon, Portugal
Redefining the set of solutions for antibiotics misuse using host response-based diagnostics.
A podcast by Dr. Kfir Oved
ECCMID 2016 - Amsterdam, Netherlands
A novel host-protein signature outperforms standard
laboratory parameters in the differential diagnosis of lower respiratory tract infections.
DLD Conference 2016 - Munich, Germany
When The Drugs Don´t Work
Pioneer Eran Eden and his MeMed team from Israel invented the impossible – a bloodtest that tells you if you are suffering from a bacterial or a viral infection and whether you should be treated with antibiotics or a simple chicken soup.
ID Week 2016 - New Orleans, USA
TNF-related apoptosis-inducing ligand (TRAIL) protein as a marker for disease severity in patients with acute infection.
AACC 2015 - Atlanta, USA
A Novel Immunoassay that distinguishes between Bacterial and Viral Infections Based on a Patient’s Immune Response.
Distinguished abstract award
ID Week 2015 - San Diego, USA
A Novel Host-Protein Signature Outperforms Standard Laboratory Parameters in Differential Diagnosis of Acute Infection Etiology of Febrile Children.
EuroMedLab 2015 - Paris, France
Automated ELISA measurements of host-immune biomarkers for distinguishing between acute bacterial and viral infections.
ICAAC 2015 - San Diego, USA
Validation of a novel host response based assay for diagnosis of acute infectious etiology in febrile children: a blinded retrospective observational study.
ESPID 2015 - Leipzig, Germany
Combining viral- and bacterial-induced host proteins for diagnosing serious bacterial infections in febrile children.
WSPID 2015 - Rio de Janeiro, Brazil
Mapping the co-occurrence of bacteria and viruses in healthy and febrile children.
ESPID 2014 - Dublin, Ireland
A novel host-proteome signature to distinguish between acute bacterial and viral infections in febrile children.
