Publications
PUBLICATION: Validation of a Multi-Analyte Immunoassay for Distinguishing Bacterial vs. Viral Infections in a Pediatric Cohort
PUBLICATION: Impact on Patient Management of a Novel Host Response Test for Distinguishing Bacterial and Viral Infections: Real World Evidence from the Urgent Care Setting
ABSTRACT: A new test, based on the measure of three non microbial host proteins, for the differentiation between bacterial and viral infections
ABSTRACT: Clinical impact of a near patient assay capable of discriminating between viral or bacterial lower respiratory tract infection in ambulatory adult patients a pilot study
PUBLICATION: Bacterial vs Viral Etiology of Fever: A Prospective Study of a Host Score for Supporting Etiologic Accuracy of Emergency Department Physicians
ABSTRACT – Host-Protein Score (integrating TRAIL, IP-10, CRP) Distinguishes between Bacterial and Viral Infection in Suspected Sepsis Patients
BV score differentiates viral from bacterial-viral co-infection in adenovirus PCR positive children
ABSTRACT: Host-Protein Score (integrating TRAIL, IP-10, CRP) Distinguishes between Bacterial and Viral Infection in Suspected Sepsis Patients, MHSRS
ABSTRACT: BV score (based on TRAIL, IP 10 and CRP) accurately distinguishes between bacterial and viral infection in febrile children: A multi cohort analysis, IDWeek 2022
ABSTRACT: Real-world use of a novel host-response test to aid physicians in distinguishing between bacterial and viral infections at outpatient urgent care centers, IDWeek 2022
ABSTRACT: A TRAIL, IP-10, CRP host-protein score distinguishes Viral from Viral-Bacterial Co-infections in Adult Patients Testing Positive for Viral Detection, RCEM 2022
A TRAIL, IP-10, CRP host-protein score distinguishes Viral from Viral-Bacterial Co-infections in Adult Patients Testing Positive for Viral Detection Dr. Jeroen Stas, Medical Science Liason, MeMed
A TRAIL, IP-10, CRP host-protein score distinguishes Viral from Viral-Bacterial Co-infections in Adult Patients Testing Positive for Viral Detection
Dr. Jeroen Stas, Medical Science Liason, MeMed
Is Your Kid’s Infection Bacterial or Viral? Eran Eden’s MeMed Can Tell
Host-Protein Score (Integrating TRAIL, IP-10, CRP) Distinguishes Between Viral and Viral-Bacterial Co-infection in Adult Patients Testing Positive for Viral Detection, AACC 2022
Validation of a Novel Semi-Quantitative Immunoassay to Differentiate Bacterial vs Viral Infections from Serum Samples
MeMed BV Distinguishes Between Viral and Bacterial Infection in Sepsis Patients, AACC 2022
Host-Protein Score (Integrating TRAIL, IP-10, CRP) Distinguishes Between Viral and Viral-Bacterial Co-Infection in Adult Patients Testing Positive for Viral Detection, ASM 2022
TRAIL, IP-10, CRP Host-Protein Signature Score Distinguishes Between Viral and Bacterial Infection in Sepsis Patients
A Host‐Protein Test Based on TRAIL, IP-10 and CRP Differentiates Between Adenoviral and Bacterial Adenoviral Co‐Infections in Children With Positive PCR‐Adenovirus Detection, ESPID 2022
BV Score’s Performance When Applied According to Indications for Use as Part Of Routine Care for Children Presenting to the ED with Fever Without Source (Spirit Study Sub Analysis), ESPID 2022
The Performance of the BV Score for Differentiating Between Bacterial and Viral Infection is Robust to Methodological Alternatives in Building the Reference Standard, ESPID 2022
A Host Signature Based on TRAIL, IP-10, and CRP For Reducing Antibiotic Overuse in Children by Differentiating Bacterial from Viral Infections: A Prospective, Multicentre Cohort Study
A Point-of-Need Platform for Rapid Measurement of a Host-Protein Score that Differentiates Bacterial from Viral Infection: Analytical Evaluation
MeMed BV Distinguishes between Viral and Bacterial Infection in Sepsis Patients, ECCMID 2022
TRAIL, IP-10, CRP Host-protein Signature score distinguishes between Viral and Bacterial Infection in Sepsis Patients, BSAC 2022
Differential Serum and Urine CRP, IP-10, and TRAIL Levels in Pediatric Urinary Tract Infection
Cost impact analysis of novel host-response diagnostic for patients with community-acquired pneumonia in the emergency department
Is It a Bacterial or Viral Infection? Using Host-Response Technologies to Decode the Immune System and Aid Antibiotic Stewardship, IDWeek 2021
Is it a bacterial or viral infection? Using host-response technologies to decode the immune system and aid antibiotic stewardship?
Dr. Debra Goff & Dr. Eran Eden
A Measurable Host Assay has Potential to Reduce Antibiotic Overuse in Adults with Suspected Lower Respiratory, AACC 2021
Leveraging the Immune Response to Improve Outbreak Management: Derivation of a Rapidly Measurable Host-Protein Signature for Stratifying Severity of COVID-19 Patients – AACC 2021
Leveraging the Immune Response to Improve Outbreak Management: Derivation of a Rapidly Measurable Host-Protein Signature for Stratifying Severity of COVID-19 Patients
MeMed Abstract – STRATIFYING SEVERITY OF COVID-19 PATIENTS
Presented by Dr. Niv Mastboim
Validating the Analytical Reproducibility of a New Chemiluminescence-based Point-of-need Platform for Multiplex Protein Measurements Across pg/ml To μg/ml Range: MeMed Key® and MeMed BV®, AACC 2021
Validating the Analytical Reproducibility of a New Chemiluminescence-based Point-of-need Platform for Multiplex Protein Measurements Across pg/ml To µg/ml Range: MeMed Key® and MeMed BV®
Presented by Dr. Einav Simon
Disruptive Technology Award Presentation, AACC 2021
AACC Disruptive Technology Finalist MeMed COVID-19 Severity
MeMed was selected as one of three finalists who presented the MeMed COVID-19 Severity™️ test at the 2021 AACC Annual Scientific Meeting in Atlanta, Georgia, on September 27th.
MeMed COVID-19 Severity is a pioneering host response technology that measures multiple proteins from a serum sample and applies machine learning to stratify the risk that a patient with COVID-19 will experience severe outcomes.
Dr. Eran Eden
An Immune-Protein Signature Combining TRAIL, IP-10 and CRP for Accurate Prediction of Severe COVID-19 Outcome
An immune-protein signature combining TRAIL, IP-10 and CRP for accurate prediction of severe COVID-19 outcome
Niv Samuel Mastboim, Alon Angel, Oded Shaham, Tahel Ilan Ber, Roy Navon, Einav Simon, Michal Rosenberg, Yael Israeli, Mary Hainrichson, Noa Avni, Eran Reiner, Paul Feigin, Kfir Oved, Boaz Tadmor, Pierre Singer, Ilya Kagan, Shaul Lev, Dror Diker, Amir Jarjou’i, Ramzi Kurd, Eli Ben-Chetrit, Guy Danziger, Cihan Papan, Sergey Motov, Ma’anit Shapira, Michal Stein, Adi Klein, Tanya M Gottlieb, Eran Eden
doi: https://doi.org/10.1101/2021.06.27.21259196
A Host-Based Assay Comprising TRAIL, IP-10, And CRP Can Improve Antibiotic Treatment Decisions for Viral PCR Positive Children by Accurately Ruling Out Co-Infection, ESPID 2021
Distinguishing Bacterial Versus Non-Bacterial Causes of Febrile Illness – A Systematic Review of Host Biomarkers
Distinguishing bacterial versus non-bacterial causes of febrile illness – A systematic review of host biomarkers
B. Leticia Fernandez-Carballo; Camille Escadafal; Emily MacLean; Anokhi J. Kapasi; Sabine Dittrich
REVIEW | VOLUME 82, ISSUE 4, P1-10, APRIL 01, 2021
Observational Cohort Study of IP-10’s Potential as a Biomarker to Aid in Inflammation Regulation Within a Clinical Decision Support Protocol for Patients with Severe COVID-19
Observational cohort study of IP-10’s potential as a biomarker to aid in inflammation regulation within a clinical decision support protocol for patients with severe COVID-19
Shaul Lev, Tamar Gottesman, Gal Sahaf Levin, Doron Lederfein, Evgeny Berkov, Dror Diker,Aliza Zaidman, Amir Nutman, Tahel Ilan Ber, Alon Angel, Lior Kellerman, Eran Barash, Roy Navon, Olga Boico, Yael Israeli, Michal Rosenberg, Amir Gelman, Roy Kalfon, Einav Simon, Noa Avni, Mary Hainrichson, Oren Zarchin, Tanya M. Gottlieb, Kfir Oved, Eran Eden, Boaz Tadmor
PLOS ONE | https://doi.org/10.1371/journal.pone.0245296 January 12, 2021
A Host-Response Signature Based on TRAIL, IP-10 and CRP Addresses Antibiotic Misuse Driven by Diagnostic Uncertainty, AACC 2020
A Host-Response Signature Based on TRAIL, IP-10 and CRP Addresses Antibiotic Misuse Driven by Diagnostic Uncertainty
Niv Mastboim, Alberto Argentiero, Cihan Papan, Tanya Gottlieb, Eran Barash, Liat Etshtein, Liran Shani, Einav Simon, Einat Moscoviz, Tahel Ilan-Bar, Roy Navon, Asi Cohen, Olga Boico, Ellen Bamberger, Kfir Oved, Eran Eden, Edoardo Farinelli, Ilaria Testa, Maria Bruna Pasticci, Daniele Mezzetti, Katia Perruccio, Marian Porwoll, Ummaya Hakim, Arne Simon, Johannes G. Liese, Markus Knuf, Michal Stein, Renata Yacobov, Sven Schneider, Tobias Tenenbaum, Susanna Esposito
BioBoss #26 – Eran Eden: Co-Founder and CEO of MeMed
Immune Response Can Guide COVID-19 Treatment
Update of a Clinical Prediction Model for Serious Bacterial Infections in Preschool Children by Adding a Host-Protein-Based Assay: A Diagnostic Study
Automating a New Host-protein Assay for Differentiating Bacterial from Viral Infection to Reduce Operator Hands-on Time
Automating a New Host-protein Assay for Differentiating Bacterial from Viral Infection to Reduce Operator Hands-on time.
Future Science
Shapira M, Boico O, Cohen A, Sagi R, Aharon A, Navon R, Kronenfeld G, Maler K, Pri-Or E, Stein M, Klein A, Eden E, Oved K
BioTechniques. 2018 Aug;65:93-95. doi: 10.2144/btn-2018-0028
Antibiotic Misuse in Respiratory Tract Infections in Children and Adults—A Prospective, Multicentre Study (TAILORED Treatment)
A host-protein signature is superior to other biomarkers for differentiating between bacterial and viral disease in patients with respiratory infection and fever without source: a prospective observational study.
Ashkenazi-Hoffnung L, Oved K, Navon R, Friedman T, Boico O, Paz M, Kronenfeld G, Etshtein L, Cohen A, Gottlieb TM, Eden E, Chistyakov I, Srugo I, Klein A, Ashkenazi S, Scheuerman O.
Eur J Clin Microbiol Infect Dis. 2018 Apr 26. doi: 10.1007/s10096-018-3261-3
A Novel Host-Protein Assay Outperforms Routine Parameters for Distinguishing Between Bacterial and Viral Lower Respiratory Tract Infections
A novel host-protein assay outperforms routine parameters for distinguishing between bacterial and viral lower respiratory tract infections.
Stein M, Lipman-Arens S, Oved K, Cohen A, Bamberger E, Navon R, Boico O, Friedman T, Etshtein L, Paz M, Gottlieb TM, Kriger O, Fonar Y, Pri-Or E, Yacobov R, Dotan Y, Hochberg A, Grupper M, Chistyakov I, Potasman I, Srugo I, Eden E, Klein A
Diagn Microbiol Infect Dis. 2018 Mar;90(3):206-213. doi: 10.1016/j.diagmicrobio.2017.11.011
Validation of a Novel Assay to Distinguish Bacterial and Viral Infections
Isaac Srugo, MD, et al.
Assessing the Febrile Child for Serious Infection: A Step Closer to Meaningful Rapid Results.
Assessing the Febrile Child for Serious Infection: A Step Closer to Meaningful Rapid Results.
David W. Kimberlin, Claudette L. Poole
Pediatrics. 2017 Oct;140(4). pii: e20171210. doi: 10.1542/peds.2017-1210
A Host-Protein Based Assay to Differentiate Between Bacterial and Viral Infections in Preschool Children (OPPORTUNITY): A Double-Blind, Multicentre, Validation Study
Diagnostic Accuracy of a TRAIL, IP-10 and CRP Combination for Discriminating Bacterial and Viral Etiologies at the Emergency Department
Diagnostic Accuracy of a TRAIL, IP-10 and CRP Combination for Discriminating Bacterial and Viral Etiologies at the Emergency Department.
Eran Eden, Isaac Srugo, Tanya Gottlieb, Roy Navon, Olga Boico, Asi Cohen, Ellen Bamberger, Adi Klein, Kfir Oved
J Infect. 2016 Aug;73(2):177-80. doi: 10.1016/j.jinf.2016.05.002
A Multifaceted ‘omics’ Approach for Addressing the Challenge of Antimicrobial Resistance
A Multifaceted ‘omics’ Approach for Addressing The Challenge of Antimicrobial Resistance.
A Multifaceted ‘omics’ Approach for Addressing The Challenge of Antimicrobial Resistance.
Cohen A, Bont L, Engelhard D, Moore E, Fernández D, Kreisberg-Greenblatt R, Oved K, Eden E, Hays JP
Future Microbiol. 2015;10(3):365-76. doi: 10.2217/fmb.14.127
A Novel Host-Proteome Signature for Distinguishing between Acute Bacterial and Viral Infections