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MeMed BV

Is it bacterial or viral?

Now you know in 15 minutes!

MeMed-BV-virus-bg

Since bacterial and viral infections are clinically indistinguishable, physicians are often challenged to decide whether to treat with antibiotics or not. By providing rapid, accurate host response information to differentiate bacterial and viral infections, MeMed BV® helps physicians to make faster, more informed decisions.

Diagnostic uncertainty leads to antibiotic misuse

antibiotic-misuse

Conventional tests are often insufficient because…

icon-lungs

Inaccessible
infection sites

icon-microscope 1

Often no
pathogens are
detected

icon-virus 1

False
alarms due
to colonization

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Prolonged
time to results

icon-pathogen 1

Poor performance
for emerging
pathogens

Three Biomarkers + Machine
Learning = MeMed BV

In 15 minutes from a small serum or venous whole blood sample,* the FDA-cleared MeMed BV computationally integrates the levels of three host immune proteins – TRAIL, IP-10 and CRP – into a simple score indicating the likelihood of a bacterial immune response or co-infection versus a likely viral immune response.

Biomarkers

Interpreting Results

Interpreting Results

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MeMed BV Performance

MeMed BV Performance

The FDA clinical study (Apollo) was conducted to establish the diagnostic performance of the MeMed BV test for differentiating bacterial from viral infection in patients with suspected acute bacterial or viral infection.3

MeMed BV performance independently confirmed in blinded validation and real-world evidence of >20,000 patients

Our unique emphasis on quality and breadth of clinical evidence sets MeMed apart. MeMed BV performance has been validated in multi-national, double-blind clinical studies and real world settings enrolling almost 20,000 subjects in Europe, Israel and the United States.3-13 These studies have consistently demonstrated compelling performance results in different clinical settings, age groups, and patients with different clinical syndromes.

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MeMed BV performance goals independently confirmed in unprecedented validation and real-world usage encompassing >20,000 patients.3-13

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References

  1. Centers for Disease Control and Prevention. Antibiotic use in the United States: Progress and opportunities, 2018 update. Centers for Disease Control and Prevention, Atlanta, GA. 2018.
  2. Kornblith AE, Fahimi J, Kanzaria HK, Wang RC. Predictors for under-prescribing antibiotics in children with respiratory infections requiring antibiotics. Am J Emerg Med. 2018 Feb;36(2):218-225. doi: 10.1016/j.ajem.2017.
  3. MeMed data on file. Based on secondary endpoint analysis in Apollo Clinical Study (NCT04690569).
  4. Oved K, Cohen A, Boico O, Navon R, Friedman T, Etshtein L, et al. A novel host-proteome signature for distinguishing between acute bacterial and viral infections. PloS One. 2015 Mar 18;10(3):e0120012.
  5. van Houten CB, de Groot JA, Klein A, Srugo I, Chistyakov I, de Waal W, et al. A host-protein based assay to differentiate between bacterial and viral infections in preschool children (OPPORTUNITY): A double-blind, multicentre, validation study. Lancet Infect Dis. 2017 Apr 1;17(4):431-40.
  6. Srugo I, Klein A, Stein M, Golan-Shany O, Kerem N, Chistyakov I, et al. Validation of a novel assay to distinguish bacterial and viral infections. Pediatrics. 2017 Oct 1;140(4).
  7. Eden E, Srugo I, Gottlieb T, Navon R, Boico O, Cohen A, et al. Diagnostic accuracy of a TRAIL, IP-10 and CRP combination for discriminating bacterial and viral etiologies at the Emergency Department. J Infect. 2016 Aug 1;73(2):177-80.
  8. Mor M, Paz M, Amir L, Levy I, Scheuerman O, Livni G, et al. Bacterial vs viral etiology of fever: A prospective study of a host score for supporting etiologic accuracy of emergency department physicians. PLoS One. 2023 Jan 30;18(1):e0281018.
  9. Papan C, Argentiero A, Porwoll M, Hakim U, Farinelli E, Testa I, et al. A host signature based on TRAIL, IP-10, and CRP for reducing antibiotic overuse in children by differentiating bacterial from viral infections: A prospective, multicentre cohort study. Clin Microbiol Infect. 2022 May 1;28(5):723-30.
  10. Halabi S, Shiber S, Paz M, Gottlieb TM, Barash E, Navon R, et al. Host test based on TRAIL, IP-10 and CRP for differentiating bacterial and viral respiratory tract infections in adults: Diagnostic accuracy study. Clin Microbiol Infect. 2023 Jun 1.
  11. Chokkalla AK, Tam E, Liang R, Cruz AT, Devaraj S. Validation of a multi-analyte immunoassay for distinguishing bacterial vs. viral infections in a pediatric cohort. Clin Chim Acta. 2023 Jun 1;546:117387.
  12. Kalmovich B, Rahamim-Cohen D, Shapiro Ben David S. Impact on patient management of a novel host response test for distinguishing bacterial and viral infections: Real world evidence from the urgent care setting. Biomedicines. 2023 May 22;11(5):1498.
  13. Klein A, Shapira MA, Lipman-Arens S, Bamberger E, Srugo I, Chistyakov I, et al. Diagnostic accuracy of a real-time host-protein test for infection. Pediatrics. 2023 Dec 1;152(6):e2022060441.
*MeMed BV on venous blood is 510k cleared, CE-marked and approved by the Israeli Health Administration.